Open AccessHighly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate (MIA)-induced osteoarthritis
Author(s) -
Hyun Ji Park,
Chul-Kyu Lee,
Si-Hwan Song,
Jee-Hye Yun,
Ahsa Lee,
Hee Jung Park
Publication year - 2019
Publication title -
food science and biotechnology/food science and biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 38
eISSN - 2092-6456
pISSN - 1226-7708
DOI - 10.1007/s10068-019-00679-5
Subject(s) - curcumin , osteoarthritis , chemistry , endocrinology , medicine , nitrotyrosine , chondrocyte , bioavailability , cartilage , tumor necrosis factor alpha , pharmacology , biochemistry , pathology , nitric oxide , in vitro , anatomy , nitric oxide synthase , alternative medicine
This study was performed to investigate the effects of highly bioavailable curcumin as Theracurmin ® (TC) in rats with monosodium iodoacetate (MIA)-induced osteoarthritis (OA). Seventy-seven male Wistar rats were divided into six groups: normal, negative control (MIA only), positive control (Cerebrex), and three experimental groups treated with 500, 1300, or 2600 mg/kg of TC for 5 weeks. MIA injection-induced OA caused 30% weight-bearing imbalance whereas weight bearing imbalance was significantly improved in the TC groups. Mankin scores revealed TC treatment had significantly ameliorated cartilage damage and chondrocyte decrease. The expressions of nitrotyrosine, tumor necrosis factor-α, phosphorylated nuclear factor kappa B cells, and cleaved caspase-3 were markedly increased in rat with MIA-induced OA, but the TC-treated groups exhibited a significant reduction in the number of immunoreactive cells in a dose-dependent manner. In conclusion, administration of TC contributes to the anti-arthritic effect in rat with MIA-induced OA.