Open AccessPlasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis
Author(s) -
Michelle J. Ormseth,
Joseph F. Solus,
Quanhu Sheng,
Sheau-Chiann Chen,
Fei Ye,
Qiong Wu,
Annette Oeser,
Ryan M. Allen,
Paolo Raggi,
Kasey C. Vickers,
C. Michael Stein
Publication year - 2021
Publication title -
clinical rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.835
H-Index - 82
eISSN - 1434-9949
pISSN - 0770-3198
DOI - 10.1007/s10067-020-05573-8
Subject(s) - medicine , rheumatoid arthritis , coronary artery disease , microrna , cardiology , framingham risk score , coronary atherosclerosis , population , diabetes mellitus , rheumatology , oncology , disease , gene , endocrinology , biochemistry , chemistry , environmental health
MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading to excess cardiovascular morbidity and mortality, but traditional risk factors for cardiovascular risk stratification are inadequate. In the general population, miRNAs improve cardiovascular risk estimation beyond traditional risk factors. Our objective was to develop a miRNA panel that predicts coronary atherosclerosis in RA patients.