Open Access6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis
Author(s) -
Xiaofang Zhu,
Hao Yuan,
Nengyong Ouyang,
Carroll Ann Trotman,
Thomas E. Van Dyke,
Jake Y. Chen,
Guofang Shen
Publication year - 2021
Publication title -
journal of bone and mineral metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.721
H-Index - 74
eISSN - 1435-5604
pISSN - 0914-8779
DOI - 10.1007/s00774-021-01245-y
Subject(s) - osteoclast , osteopenia , bone resorption , dental alveolus , rankl , resorption , chemistry , osteoblast , dentistry , medicine , endocrinology , osteoporosis , bone mineral , in vitro , activator (genetics) , biochemistry , receptor
Corticotomy is widely used in clinical practice to accelerate tooth movement and shorten the duration of orthodontic treatment. It is effective, but an invasive surgery is needed to induce alveolar bone osteopenia that enable rapid tooth movement. In this study, we discovered the potential of 6-shogaol as a more patient-friendly non-invasive alternative to induce transient osteopenia and accelerate tooth movement.