Open AccessIntegrity of dural closure after autologous platelet rich fibrin augmentation: an in vitro study
Author(s) -
Ioannis Vasilikos,
Jürgen Beck,
Shahram Ghanaati,
Juergen Grauvogel,
Themistoklis Nisyrios,
Konstantinos Grapatsas,
Ulrich Hubbe
Publication year - 2020
Publication title -
acta neurochirurgica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.742
H-Index - 95
eISSN - 0942-0940
pISSN - 0001-6268
DOI - 10.1007/s00701-020-04254-4
Subject(s) - dura mater , platelet rich fibrin , leak , fibrin , fibrous joint , medicine , fibrin tissue adhesive , cerebrospinal fluid leak , surgery , intracranial pressure , biomedical engineering , fibrin glue , pathology , cerebrospinal fluid , environmental engineering , engineering , immunology
Watertight closure of the dura mater is fundamental in neurosurgery. Besides the classical suturing techniques, a variety of biomaterials have been proposed as sealants. Platelet rich fibrin (PRF) is an autologous biomaterial which can readily be obtained through low-speed centrifugation of patient's own blood. It is rich in fibrin, growth factors, leucocytes and cytokines and has shown adhesive properties while promoting the physiological wound healing process. In this study, we investigated the effect of applying PRF in reinforcing the watertight dura mater closure.