Open AccessNovel Mutations of Neurofibromatosis Type 1 Gene in Small Cell Lung Cancers
Author(s) -
KenIchi Furukawa,
Noboru Yanai,
Michiya Fujita,
Yukio Harada
Publication year - 2003
Publication title -
surgery today
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 63
eISSN - 1436-2813
pISSN - 0941-1291
DOI - 10.1007/s005950300074
Subject(s) - neurofibromatosis , lung cancer , transition (genetics) , medicine , mutation , gene , cancer research , carcinogenesis , point mutation , genetics , microbiology and biotechnology , pathology , biology
Mutations in the GTPase-activating protein-related domain (GRD) of the von Recklinghausen neurofibromatosis type 1 (NF1) gene have been reported in several tumors that were not previously associated with NF1. We analyzed 37 cases of lung cancer, including 9 cases of small cell carcinoma, to detect mutations in this domain.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom