Open AccessLow metabolic activity in primary gastric adenocarcinoma is associated with resistance to chemoradiation and the presence of signet ring cells
Author(s) -
Kazuto Harada,
Madhavi Patnana,
Xuemei Wang,
Masaaki Iwatsuki,
Mariela A. Blum Murphy,
Meina Zhao,
Prajnan Das,
Bruce D. Minsky,
Brian Weston,
Jeffrey H. Lee,
Manoop S. Bhutani,
Jeannelyn S. Estrella,
Namita Shanbhag,
Naruhiko Ikoma,
Brian D. Badgwell,
Jaffer A. Ajani
Publication year - 2020
Publication title -
surgery today
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 63
eISSN - 1436-2813
pISSN - 0941-1291
DOI - 10.1007/s00595-020-02018-2
Subject(s) - medicine , adenocarcinoma , surgical oncology , confidence interval , signet ring cell , positron emission tomography , odds ratio , signet ring cell carcinoma , standardized uptake value , gastroenterology , cancer , oncology , nuclear medicine
Preoperative chemoradiation is a potential treatment option for localized gastric adenocarcinoma (GAC). Currently, the response to chemoradiation cannot be predicted. We analyzed the pretreatment maximum standardized uptake value (SUV max ) and total lesion glycolysis (TLG) on positron emission tomography/computed tomography as potential predictors of the response to chemoradiation.