Open AccessThe haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study
Author(s) -
Jinghui Ju,
Erin L. Tomaszewski,
Trevor J. Orchard,
Rhobert W. Evans,
Eleanor Feingold,
Tina Costacou
Publication year - 2019
Publication title -
acta diabetologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.141
H-Index - 67
eISSN - 1432-5233
pISSN - 0940-5429
DOI - 10.1007/s00592-019-01422-6
Subject(s) - medicine , diabetes mellitus , logistic regression , odds ratio , genotype , haptoglobin , coronary artery disease , type 2 diabetes , type 1 diabetes , cardiology , risk factor , gastroenterology , endocrinology , biology , biochemistry , gene
The haptoglobin (Hp) 2-2 genotype has been shown to increase the risk of coronary artery disease, kidney dysfunction and mortality from cardiovascular and renal causes in type 1 diabetes (T1D). Similar associations, however, have not been observed in those without diabetes. As cardiac autonomic neuropathy (CAN) is a cardiovascular disease risk factor, we assessed the presence of an association between the Hp 2-2 genotype and CAN.