The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study | Zendy

Jinghui Ju | Zendy; Erin L. Tomaszewski | Zendy; Trevor J. Orchard | Zendy; Roger G. Evans | Zendy; Eleanor Feingold | Zendy; Tina Costacou | Zendy

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The haptoglobin 2-2 genotype is associated with cardiac autonomic neuropathy in type 1 diabetes: the RETRO HDLc study

Author(s) -

Jinghui Ju,

Erin L. Tomaszewski,

Trevor J. Orchard,

Roger G. Evans,

Eleanor Feingold,

Tina Costacou

Publication year - 2019

Publication title -

acta diabetologica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.141

H-Index - 67

eISSN - 1432-5233

pISSN - 0940-5429

DOI - 10.1007/s00592-019-01422-6

Subject(s) - medicine , diabetes mellitus , logistic regression , odds ratio , genotype , haptoglobin , coronary artery disease , type 2 diabetes , type 1 diabetes , cardiology , risk factor , gastroenterology , endocrinology , biology , biochemistry , gene

The haptoglobin (Hp) 2-2 genotype has been shown to increase the risk of coronary artery disease, kidney dysfunction and mortality from cardiovascular and renal causes in type 1 diabetes (T1D). Similar associations, however, have not been observed in those without diabetes. As cardiac autonomic neuropathy (CAN) is a cardiovascular disease risk factor, we assessed the presence of an association between the Hp 2-2 genotype and CAN.

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