Open AccessThe 1-h post-load plasma glucose as a novel biomarker for diagnosing dysglycemia
Author(s) -
Ram Jagannathan,
Martin Buysschaert,
J. L. Medina,
Karin Katz,
Sarah Musleh,
Brenda Dorcely,
Michael Bergman
Publication year - 2018
Publication title -
acta diabetologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.141
H-Index - 67
eISSN - 1432-5233
pISSN - 0940-5429
DOI - 10.1007/s00592-018-1105-3
Subject(s) - prediabetes , medicine , diabetes mellitus , biomarker , type 2 diabetes , impaired glucose tolerance , population , plasma glucose , impaired fasting glucose , glucose tolerance test , endocrinology , insulin resistance , biology , environmental health , biochemistry
Identifying the earliest moment for intervention to avert progression to prediabetes and diabetes in high-risk individuals is a substantial challenge. As β-cell function is already compromised in prediabetes, attention should therefore be focused on identifying high-risk individuals earlier in the so-called pre-prediabetes stage. Biomarkers to monitor progression and identify the time point at which β-cell dysfunction occurs are therefore critically needed. Large-scale population studies have consistently shown that the 1-h plasma glucose (1-h PG) ≥ 155 mg/dl (8.6 mmol/l) during the oral glucose tolerance test detected incident type 2 diabetes and associated complications earlier than fasting plasma glucose or 2-h plasma glucose levels. An elevated 1-h PG level appears to be a better alternative to HbA1c [5.7-6.4% (37-47 mmol/mol)] or traditional glucose criteria for identifying high-risk individuals at a stage when ß-cell function is substantially more intact than in prediabetes. Diagnosing high-risk individuals earlier proffers the opportunity for potentially reducing progression to diabetes, development of microvascular complications and mortality, thereby advancing benefit beyond that which has been demonstrated in global diabetes prevention programs.