Landiolol, an ultra short acting β1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats | Zendy

Masahiro Uraoka | Zendy; Yoshiki Nakajima | Zendy; Tadayoshi Kurita | Zendy; Akira Suzuki | Zendy; Kotaro Takata | Zendy; Shigehito Sato | Zendy

Open Access

Landiolol, an ultra short acting β1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats

Author(s) -

Masahiro Uraoka,

Yoshiki Nakajima,

Tadayoshi Kurita,

Akira Suzuki,

Kotaro Takata,

Shigehito Sato

Publication year - 2009

Publication title -

journal of anesthesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.599

H-Index - 44

eISSN - 1438-8359

pISSN - 0913-8668

DOI - 10.1007/s00540-009-0834-4

Subject(s) - medicine , epinephrine , anesthesia , cardiopulmonary resuscitation , pulmonary edema , resuscitation , lung

Epinephrine is frequently administered as an essential drug for cardiopulmonary resuscitation (CPR) in clinical situations. Unfortunately, epinephrine elicits unfavorable effects, for example pulmonary edema, both during and after CPR. We hypothesized that administration of landiolol during CPR with epinephrine would reduce the degree of pulmonary edema and improve survival. Therefore using a rat CPR model, we investigated the effect of landiolol with epinephrine on pulmonary and cardiac injury following CPR.

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