Usefulness of p53 gene mutations in the supernatant of bile for diagnosis of biliary tract carcinoma: comparison with K- ras mutation | Zendy

Ying Wang | Zendy; Yasushi Yamaguchi | Zendy; Hiroyuki Watanabe | Zendy; Koushiro Ohtsubo | Zendy; Tokio Wakabayashi | Zendy; Norio Sawabu | Zendy

Open Access

Usefulness of p53 gene mutations in the supernatant of bile for diagnosis of biliary tract carcinoma: comparison with K- ras mutation

Author(s) -

Ying Wang,

Yasushi Yamaguchi,

Hiroyuki Watanabe,

Koushiro Ohtsubo,

Tokio Wakabayashi,

Norio Sawabu

Publication year - 2002

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 114

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s005350200137

Subject(s) - mutation , mutant , hepatology , exon , gene , biliary tract , polymerase chain reaction , biology , microbiology and biotechnology , carcinoma , gene mutation , allele , medicine , genetics

The sensitivity of bile cytology for the diagnosis of biliary tract carcinoma (BTCa) is still low. In addition, the incidence of detection of genetic mutations in the bile of BTCa is not satisfactory yet. To improve the molecular diagnosis of BTCa, we analyzed p53 and K- ras mutations in DNA extracted from not only the sediment but the supernatant of bile samples.

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