Enhanced endoscopic detection of occult gastric cancer in carriers of pathogenic CDH1 variants | Zendy

Bryan F. Curtin | Zendy; Lauren A. Gamble | Zendy; Samuel A. Schueler | Zendy; Samantha M. Ruff | Zendy; Martha Quezado | Zendy; Markku Miettinen | Zendy; GraceAnn Fasaye | Zendy; Monica Passi | Zendy; Jonathan M. Hernandez | Zendy; Theo Heller | Zendy; Christopher Koh | Zendy; Jeremy L. Davis | Zendy

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Enhanced endoscopic detection of occult gastric cancer in carriers of pathogenic CDH1 variants

Author(s) -

Bryan F. Curtin,

Lauren A. Gamble,

Samuel A. Schueler,

Samantha M. Ruff,

Martha Quezado,

Markku Miettinen,

GraceAnn Fasaye,

Monica Passi,

Jonathan M. Hernandez,

Theo Heller,

Christopher Koh,

Jeremy L. Davis

Publication year - 2020

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s00535-020-01749-w

Subject(s) - hepatology , occult , surgical oncology , cdh1 , medicine , abdominal surgery , cancer , colorectal surgery , gastroenterology , general surgery , pathology , biology , genetics , cadherin , alternative medicine , cell

Germline inactivating variants in the CDH1 tumor suppressor gene impart an elevated lifetime risk of diffuse gastric cancer. The current endoscopic surveillance method depends upon random gastric biopsies for early cancer detection.

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