Open AccessEnhanced endoscopic detection of occult gastric cancer in carriers of pathogenic CDH1 variants
Author(s) -
Bryan F. Curtin,
Lauren A. Gamble,
Samuel A. Schueler,
Samantha M. Ruff,
Martha Quezado,
Markku Miettinen,
GraceAnn Fasaye,
Monica Passi,
Jonathan M. Hernandez,
Theo Heller,
Christopher Koh,
Jeremy L. Davis
Publication year - 2020
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-020-01749-w
Subject(s) - medicine , cancer , signet ring cell carcinoma , context (archaeology) , surgical oncology , gastroenterology , asymptomatic , surgery , adenocarcinoma , paleontology , biology
Germline inactivating variants in the CDH1 tumor suppressor gene impart an elevated lifetime risk of diffuse gastric cancer. The current endoscopic surveillance method depends upon random gastric biopsies for early cancer detection.