Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance | Zendy

Tetsuhiro Okada | Zendy; Yusuke Mizukami | Zendy; Yusuke Ono | Zendy; Hiroki Sato | Zendy; Akihiro Hayashi | Zendy; Hidemasa Kawabata | Zendy; Kazuya Koizumi | Zendy; Sakue Masuda | Zendy; Shinichi Teshima | Zendy; Kuniyuki Takahashi | Zendy; Akio Katanuma | Zendy; Yuko Omori | Zendy; Hirotoshi Iwano | Zendy; Masataka Yamada | Zendy; Tomoki Yokochi | Zendy; Shingo Asahara | Zendy; Kazumichi Kawakubo | Zendy; Masaki Kuwatani | Zendy; Naoya Sakamoto | Zendy; Katsuro Enomoto | Zendy; Takuma Goto | Zendy; Junpei Sasajima | Zendy; Mikihiro Fujiya | Zendy; Jun Ueda | Zendy; Seiji Matsumoto | Zendy; Kenzui Taniue | Zendy; Ayumu Sugitani | Zendy; Hidenori Karasaki | Zendy; Toshikatsu Okumura | Zendy

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Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance

Author(s) -

Tetsuhiro Okada,

Yusuke Mizukami,

Yusuke Ono,

Hiroki Sato,

Akihiro Hayashi,

Hidemasa Kawabata,

Kazuya Koizumi,

Sakue Masuda,

Shinichi Teshima,

Kuniyuki Takahashi,

Akio Katanuma,

Yuko Omori,

Hirotoshi Iwano,

Masataka Yamada,

Tomoki Yokochi,

Shingo Asahara,

Kazumichi Kawakubo,

Masaki Kuwatani,

Naoya Sakamoto,

Katsuro Enomoto,

Takuma Goto,

Junpei Sasajima,

Mikihiro Fujiya,

Jun Ueda,

Seiji Matsumoto,

Kenzui Taniue,

Ayumu Sugitani,

Hidenori Karasaki,

Toshikatsu Okumura

Publication year - 2020

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 114

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s00535-020-01724-5

Subject(s) - surgical oncology , digital polymerase chain reaction , hepatology , abdominal surgery , stage (stratigraphy) , colorectal surgery , medicine , mutation , pancreatic cancer , polymerase chain reaction , dna , cancer research , oncology , gene , biology , genetics , cancer , paleontology

Cell-free DNA (cfDNA) shed from tumors into the circulation offers a tool for cancer detection. Here, we evaluated the feasibility of cfDNA measurement and utility of digital PCR (dPCR)-based assays, which reduce subsampling error, for diagnosing pancreatic ductal adenocarcinoma (PDA) and surveillance of intraductal papillary mucinous neoplasm (IPMN).

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