Open AccessConstant-severe pain in chronic pancreatitis is associated with genetic loci for major depression in the NAPS2 cohort
Author(s) -
Ellyn Dunbar,
Phil J. Greer,
Nadine M. Melhem,
Samer Alkaade,
Stephen T. Amann,
Randall E. Brand,
Gregory A. Coté,
Christopher E. Forsmark,
Timothy B. Gardner,
Andrés Gelrud,
Nalini M. Guda,
Jessica LaRusch,
Michele D. Lewis,
Jorge D. Machicado,
Thiruvengadam Muniraj,
Georgios I. Papachristou,
Joseph Romagnuolo,
Bimaljit S. Sandhu,
Stuart Sherman,
C. Mel Wilcox,
Vikesh K. Singh,
Dhiraj Yadav,
David C. Whitcomb
Publication year - 2020
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-020-01703-w
Subject(s) - depression (economics) , medicine , pancreatitis , chronic pain , psychiatry , economics , macroeconomics
Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients.