Open AccessEpitope peptides of Helicobacter pylori CagA antibodies from sera by whole-peptide mapping
Author(s) -
Shamshul Ansari,
Junko Akada,
Yuichi Matsuo,
Seiji Shiota,
Yoko Kudo,
Tadayoshi Okimoto,
Kazunari Murakami,
Yoshio Yamaoka
Publication year - 2019
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-019-01584-8
Subject(s) - caga , epitope , peptide , helicobacter pylori , immunogenicity , antibody , amino acid , microbiology and biotechnology , peptide sequence , biology , biochemistry , chemistry , immunology , genetics , gene , virulence
Helicobacter pylori CagA has been found to be immuno-dominant protein and utilized for the diagnosis of the infection with cagA-positive strains. It is important to characterize the peptide epitopes capable of detecting serum anti-CagA antibodies to understand CagA immunogenicity.