Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats | Zendy

Tsukasa Nozu | Zendy; Saori Miyagishi | Zendy; Rintaro Nozu | Zendy; Kaoru Takakusaki | Zendy; Toshikatsu Okumura | Zendy

Open Access

Lipopolysaccharide induces visceral hypersensitivity: role of interleukin-1, interleukin-6, and peripheral corticotropin-releasing factor in rats

Author(s) -

Tsukasa Nozu,

Saori Miyagishi,

Rintaro Nozu,

Kaoru Takakusaki,

Toshikatsu Okumura

Publication year - 2016

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 114

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s00535-016-1208-y

Subject(s) - medicine , endocrinology , visceral pain , receptor antagonist , lipopolysaccharide , antagonist , allodynia , irritable bowel syndrome , interleukin , corticotropin releasing hormone , receptor , stimulation , cytokine , hyperalgesia , nociception

Lipopolysaccharide (LPS) induces visceral hypersensitivity, and corticotropin-releasing factor (CRF) also modulates visceral sensation. Besides, LPS increases CRF immunoreactivity in rat colon, which raises the possibility of the existence of a link between LPS and the CRF system in modulating visceral sensation. The present study tried to clarify this possibility.

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