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Endogenous orexin-A in the brain mediates 2-deoxy-d-glucose-induced stimulation of gastric motility in freely moving conscious rats
Author(s) -
Tsukasa Nozu,
Yoshihiro Tuchiya,
Shima Kumei,
Kaoru Takakusaki,
Koji Ataka,
Mineko Fujimiya,
Toshikatsu Okumura
Publication year - 2011
Publication title -
journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.33
H-Index - 114
eISSN - 1435-5922
pISSN - 0944-1174
DOI - 10.1007/s00535-011-0506-7
Subject(s) - orexin a , medicine , endocrinology , stimulation , orexin , atropine , gastric acid , antagonist , motility , neuropeptide , stomach , biology , receptor , genetics
Increasing evidence has indicated that brain orexin plays a vital role in the regulation of gastrointestinal (GI) physiology such as gastric acid secretion and GI motility. The aim of this study was to elucidate the effects and mechanisms of orexin on gastric motility in non-fasted rats.

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