Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters | Zendy

Koushiro Ohtsubo | Zendy; Hiroyuki Watanabe | Zendy; Yasushi Yamaguchi | Zendy; Yuxin Hu | Zendy; Yoshiharu Motoo | Zendy; Takashi Okai | Zendy; Norio Sawabu | Zendy

Open Access

Abnormalities of tumor suppressor gene p16 in pancreatic carcinoma: immunohistochemical and genetic findings compared with clinicopathological parameters

Author(s) -

Koushiro Ohtsubo,

Hiroyuki Watanabe,

Yasushi Yamaguchi,

Yuxin Hu,

Yoshiharu Motoo,

Takashi Okai,

Norio Sawabu

Publication year - 2003

Publication title -

journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.33

H-Index - 114

eISSN - 1435-5922

pISSN - 0944-1174

DOI - 10.1007/s00535-003-1119-6

Subject(s) - immunohistochemistry , pathology , biology , carcinoma , pancreatic cancer , tumor suppressor gene , carcinogenesis , cancer , medicine , genetics

Abnormalities of the tumor suppressor gene p16 have been reported in a variety of human tumors but are rare in pancreatic carcinoma except for cancer cell lines and xenografts. Their clinicopathological significance remains unknown. The purpose of this study was to examine immunohistochemical and genetic alterations of p16 in primary pancreatic carcinoma tissues and to investigate the relation between abnormalities of p16 and clinicopathological parameters to elucidate their clinicopathological significance.

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