Premium
Generation of islets of Langerhans from adult pancreatic stem cells
Author(s) -
Peck Ammon B.,
Cornelius Janet G.,
Schatz Desmond,
Ramiya Vijayakumar K.
Publication year - 2002
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340200097
Subject(s) - islet , stem cell , in vitro , pancreas , pancreatic islets , biology , microbiology and biotechnology , multipotent stem cell , enteroendocrine cell , neovascularization , adult stem cell , insulin , endocrinology , medicine , endocrine system , angiogenesis , cancer research , endothelial stem cell , progenitor cell , hormone , biochemistry
Ductal structures of the adult pancreas contain multipotent stem cells that, under controlled in vitro conditions, are able to self‐renew and differentiate into functional islets of Langerhans. In vitro‐generated islets, whether derived from stem cells of human, porcine, or mouse origin, exhibit temporal changes in mRNA transcripts for islet‐associated markers as well as regulated insulin responses following glucose challenge. When in vitro‐generated mouse islets were implanted into diabetic mice, neovascularization of the implant material occurred, followed by reversal of insulin‐dependent diabetes. The possibility of growing functional islets from adult stem cells provides new opportunities to produce large numbers of islets, even autologous islets, for use as implants.