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New approaches for successful islet transplantation
Author(s) -
Gotoh Mitsukazu,
Sato Yoshihiro,
Abe Tsuyoshi,
Kanazawa Yukio
Publication year - 2000
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340070029
Subject(s) - islet , transplantation , pancreas , islet cell transplantation , pancreas transplantation , pancreatic islets , biology , medicine , insulin , endocrinology , kidney transplantation
The long‐term control of glucose metabolism is expected to be achieved with insulin‐secreting pancreatic islets transplanted as the whole pancreas or isolated islet tissue. The current clinical outcomes of such procedures are unsatisfactory compared with that of whole organ transplantation or experimental islet transplantation, although the safety of the transplantation procedure itself is assured. In this review, we first describe the immunological characteristics of purified islets in an attempt to explain the differences between the results for human and experimental islet transplantation. We then introduce new approaches currently undertaken in our laboratory that could, we hope, make islet transplantation more successful.