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Hepatoid adenocarcinoma of the gallbladder
Author(s) -
Nakashima Hiroshi,
Nagafuchi Kazumitsu,
Satoh Hiroshi,
Takeda Kazuhisa,
Yamasaki Toru,
Yonemasu Hirotoshi,
Kishikawa Hideki
Publication year - 2000
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340050181
Subject(s) - gallbladder , eosinophilic , gallbladder cancer , medicine , adenocarcinoma , immunohistochemistry , cholecystectomy , lymph node , pathology , dissection (medical) , cancer , general surgery , gastroenterology , radiology
We describe here a rare case of hepatoid adenocarcinoma (HAC) of the gallbladder without the production of alpha‐fetoprotein (AFP). A 77‐year‐old man was referred to our division with complaints of general fatigue, loss of appetite, and loss of body weight. A preoperative diagnosis of advanced gallbladder cancer was made, and cholecystectomy with combined resection of two liver subsegments (S4a + S5) and lymph node dissection were performed. Microscopically, the tumor was mainly composed of characteristic cells featuring eosinophilic cytoplasm, enlarged nuclei, and prominent nucleoi, arranged in nests or proliferated in a trabecular pattern. These features were highly suggestive of HAC of the gallbladder, and the tumor cells were negative for AFP immunohistochemical staining. The patient is doing well and has survived for 15 months postoperatively without any recurrence.