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Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct
Author(s) -
Hanada Keiji,
Tsuchida Akira,
Kajiyama Goro
Publication year - 1999
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340050111
Subject(s) - gallbladder , dysplasia , carcinogenesis , carcinoma , malignancy , pathology , bile duct , cancer research , cystic duct , medicine , biology , gastroenterology , cancer
Anomalous junction of the pancreaticobiliary duct (AJPBD) is thought to be an important risk factor for gallbladder carcinoma in Japan. We have reported the characteristic pathology, cellular kinetics, and gene mutations to clarify the mechanism of carcinogenesis in gallbladder mucosa with AJPBD. A comprehensive review of the literature was undertaken, with referencing of major articles on the subject. A sequence of hyperplastic changes, with a corresponding increase in cellular kinetics with progression through dysplasia to carcinoma is important in carcinogenesis of gallbladder mucosa with AJPBD. p53 mutations may contribute to the transition from premalignancy to malignancy in the early stage of carcinogenesis of the gallbladder mucosa, regardless of the presence of AJPBD. The specific mutation of GGT‐to‐GAT in codon 12 of K‐ ras may play an important role in carcinogenesis of gallbladder mucosa with AJPBD.