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Apoptosis and the liver: Relevance for the hepato‐biliary‐pancreatic surgeon
Author(s) -
Miyoshi Hideyuki,
Gores Gregory J.
Publication year - 1998
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340050065
Subject(s) - apoptosis , cholestasis , caspase , fas ligand , programmed cell death , medicine , intrinsic apoptosis , signal transduction , pathophysiology , pancreatic cancer , intracellular , cancer research , pathology , cancer , biology , microbiology and biotechnology , biochemistry
Cell death by apoptosis is thought to be involved in various pathophysiological situations involving the liver. Indeed, an understanding of apoptosis is becoming increasingly helpful for understanding disease and for patients' care. In this article, we review current scientific and clinical concepts of apoptosis, including death factors such as Fas ligand and tumor necrosis factor, apoptotic signal transduction mechanisms, and the role of intracellular proteinases called caspases. We also discuss apoptosis in the liver, as related to ischemia/reperfusion injury, cholestasis, and cancer, circumstances which physicians often face in the field of the liver surgery.