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Solitary fibrous tumor of the liver with CD 34 positivity and hypoglycemia
Author(s) -
Guglielmi Alfredo,
Frameglia Matteo,
Iuzzolino Paolo,
Martigi Guido,
Manzoni Giovanni,
Laterza Ernesto,
Veraldi Gian Franco,
Girlanda Raffaele
Publication year - 1998
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s005340050036
Subject(s) - solitary fibrous tumor , hypoglycemia , medicine , pathology , computed tomography , immunohistochemistry , surgery , biology , stem cell , genetics , cd34 , insulin
We report a new case of solitary fibrous tumor (SFT) of the liver, an extremely rare neoplasm. Including the present case no more than ten cases are reported in the English‐language literature. To date there is no definite proof of the origin of this tumor. Both mesothelial and fibroblas‐tic genesis has been postulated. The monoclonal antibody CD 34 has recently been used for the characterization of SFT. SFT would appear to be histogenetically related to a CD 34 — positive fibroblastic stem cell. A 61‐year‐old woman was admitted to our department with epigastric and right hypochondriac pain, weight loss, and hypoglycemia. Ultrasonography and computed tomography demonstrated a large heterogeneous mass in the right hepatic lobe. A right hepatectomy was performed. The tumor weighed 2850 g and microscopic section revealed a peculiar random pattern, the so‐called patternless pattern of spindle tumor cells separated by abundant thick collagen bands. The tumor presented a number of highly cellular areas composed of plump spindle cell with hyperchromatic nuclei and rare mitotic figures. Ninety percent of the neoplastic cells displayed strong immunoreactivity for CD 34/My 10. The postoperative course was uneventful and the patient is alive and well without recurrence 6 years after surgery.

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