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Inflammation‐based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma
Author(s) -
Oshiro Yukio,
Sasaki Ryoko,
Fukunaga Kiyoshi,
Kondo Tadashi,
Oda Tatsuya,
Takahashi Hideto,
Ohkohchi Nobuhiro
Publication year - 2013
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-012-0550-6
Subject(s) - medicine , proportional hazards model , pathological , univariate analysis , stage (stratigraphy) , gastroenterology , oncology , cancer , multivariate analysis , paleontology , biology
Background/purpose Recent studies have revealed that the Glasgow prognostic score (GPS), an inflammation‐based prognostic score, is useful for predicting outcome in a variety of cancers. This study sought to investigate the significance of GPS for prognostication of patients who underwent surgery with extrahepatic cholangiocarcinoma. Methods We retrospectively analyzed a total of 62 patients who underwent resection for extrahepatic cholangiocarcinoma. We calculated the GPS as follows: patients with both an elevated C‐reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L) were allocated a score of 2; patients with one or none of these abnormalities were allocated a score of 1 or 0, respectively. Prognostic significance was analyzed by the log‐rank test and a Cox proportional hazards model. Results Overall survival rate was 25.5 % at 5 years for all 62 patients. Venous invasion ( p = 0.01), pathological primary tumor category ( p = 0.013), lymph node metastasis category ( p < 0.001), TNM stage ( p < 0.001), and GPS ( p = 0.008) were significantly associated with survival by univariate analysis. A Cox model demonstrated that increased GPS was an independent predictive factor with poor prognosis. Conclusions The preoperative GPS is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.