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Pancreatic cancer stem cells: regulatory networks in the tumor microenvironment and targeted therapy
Author(s) -
Takao Sonshin,
Ding Qiang,
Matsubara Shyuichiro
Publication year - 2012
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-012-0547-1
Subject(s) - pancreatic cancer , tumor microenvironment , cancer stem cell , cancer research , cancer , medicine , stem cell , tumor progression , oncology , biology , tumor cells , microbiology and biotechnology
Abstract Recent evidence has demonstrated that the existence of a cancer stem cell (CSC) subset in a solid tumor is responsible for the progression and relapse of cancer as well as its resistance to current therapies. Over the past decade, CSC research on pancreatic cancer has progressed. A fundamental understanding of pancreatic CSCs may improve therapies and deepen insight into the role of cell—cell interactions within a tumor microenvironment in pancreatic cancer progression. This review focuses on the impact of pancreatic CSCs on the regulatory networks in the tumor microenvironment, and the implications of targeting CSCs to treat pancreatic cancer.