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Area between the hepatic and heart curves of 99m Tc‐galactosyl‐human serum albumin scintigraphy represents liver function and disease progression for preoperative evaluation in hepatocellular carcinoma patients
Author(s) -
Harada Kohei,
Mizuguchi Toru,
Katagiri Yoshimi,
Kawamoto Masaki,
Nakamura Yukio,
Meguro Makoto,
Ota Shigenori,
Sasaki Shigeru,
Miyanishi Koji,
Sonoda Tomoko,
Mori Mitsuru,
Shinomura Yasuhisa,
Kato Junji,
Hirata Koichi
Publication year - 2012
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-011-0486-2
Subject(s) - receiver operating characteristic , cirrhosis , medicine , liver function , hepatocellular carcinoma , hepatectomy , scintigraphy , gastroenterology , albumin , area under the curve , liver function tests , liver disease , bilirubin , asialoglycoprotein receptor , nuclear medicine , surgery , resection , hepatocyte , chemistry , biochemistry , in vitro
Background/purpose We developed software to calculate the pixels of interest in the area between the hepatic and heart curves (ABC) of 99m Tc‐galactosyl human serum albumin (GSA) scintigraphy. The aim of this study was to examine the accuracy of the ABC to evaluate liver function before hepatectomy. Methods Between January 2005 and December 2010, 205 consecutive patients who underwent initial hepatectomy were enrolled in this study. The ABC was calculated using original computer software. The area under the receiver operating characteristic curve (AUC) was calculated for evaluation of Child—Pugh score grade B (Child B), pathological chronic hepatitis (CH), and liver cirrhosis (LC). Results The AUC of any indicator for Child B was more than 0.900 except bilirubin. The AUC of ABC for CH and LC (AUC 0.734 each) was comparable to those of HH15 (clearance index; AUC 0.704 and 0.700, respectively) and LHL15 (receptor index; AUC 0.703 and 0.706, respectively) in multiple receiver operating characteristic comparison. Conclusions We have developed a novel liver function indicator, the ABC, to count radioactivity in sequence. The ABC reflects liver function according to pathological deterioration of the liver. Although the ABC gave no significant advantage compared to HH15 and LHL15, it improved the AUC evaluation by 0.028–0.034.