Premium
Branched‐chain amino acid‐enriched nutrients improve nutritional and metabolic abnormalities in the early post‐transplant period after living donor liver transplantation
Author(s) -
Yoshida Ryuichi,
Yagi Takahito,
Sadamori Hiroshi,
Matsuda Hiroaki,
Shinoura Susumu,
Umeda Yuzo,
Sato Daisuke,
Utsumi Masashi,
Nagasaka Takeshi,
Okazaki Nami,
Date Ai,
Noguchi Ayako,
Tanaka Akemi,
Hasegawa Yuko,
Sakamoto Yachiyo,
Fujiwara Toshiyoshi
Publication year - 2012
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-011-0459-5
Subject(s) - liver transplantation , medicine , gastroenterology , nutrient , transplantation , respiratory quotient , randomized controlled trial , perioperative , malnutrition , liver disease , biology , surgery , ecology
Background/purpose Malnutrition and metabolic disorder of patients undergoing living donor liver transplantation (LDLT) can affect post‐transplant prognosis. The aim of this study was to establish whether perioperative usage of branched‐chain amino‐acid (BCAA)‐enriched nutrients improve metabolic abnormalities of patients undergoing LDLT. Methods We designed a randomized pilot study (UMIN registration number; 4323). Twenty‐five consecutive adult elective LDLT recipients were enroled and divided into two groups: the BCAA group (BCAA‐enriched nutrients, n = 12) and the control group (standard diet, n = 13). Metabolic and nutritional parameters, including BCAA‐to‐tyrosine ratio (BTR), retinol binding protein (RBP), and prealbumin were regularly measured from 1 week before to 4 weeks after LDLT. Non‐protein respiratory quotient (npRQ) was measured before and 4 weeks after LDLT. Results BTR and RBP improved considerably in the BCAA group compared with the controls. npRQ significantly increased from 1 week before LDLT to 4 weeks after LDLT in the BCAA group (0.77 ± 0.05 to 0.84 ± 0.06, P = 0.002), but not in the control group (0.78 ± 0.04 to 0.81 ± 0.05). Conclusions Supplementation with BCAA‐enriched nutrients might improve persistent nutritional and metabolic disorders associated with end‐stage liver disease in the early post‐transplant period, and consequently shorten the post‐transplant catabolic phase after LDLT. A larger multicenter trial is needed to confirm these findings.