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Tri‐iodothyronine enhances liver regeneration after living donor liver transplantation in rats
Author(s) -
TakiEldin Ahmed,
Zhou Lin,
Xie HaiYang,
Chen Kangjie,
Zhou Wuhua,
Zhang Wu,
Xing ChunYang,
Yang Zhe,
Zhang Kai,
Zheng ShuSen
Publication year - 2011
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-011-0397-2
Subject(s) - liver regeneration , cyclin d1 , hepatocyte , regeneration (biology) , medicine , endocrinology , liver transplantation , western blot , transplantation , body weight , biology , andrology , cell cycle , chemistry , cancer , microbiology and biotechnology , biochemistry , in vitro , gene
Background Tri‐iodothyronine (T3) has been shown to be a hepatic mitogen. The aim of this study was to evaluate the effect of T3 on liver regeneration after 50% partial liver transplantation (pLT) in rats. Methods Immediately after pLT, a single dose of T3 (4 mg/kg body weight) was administered. Liver/body weight ratio (LBWR), hepatocyte proliferation (Ki‐67), biochemical parameters, and changes in cell cycle related proteins were evaluated. Results T3 promoted liver regeneration as shown by an increased liver/body weight ratio and Ki‐67 proliferation index after pLT. On the transcriptional level, T3‐treated rats had an increased expression of cyclin D1 and cyclin A as demonstrated by real time RT‐PCR and Western blot. Conclusions Exogenous administration of T3 significantly improved liver regeneration after pLT, and therefore it may represent a promising strategy to improve the clinical outcome after living donor liver transplantation in the future.