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Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Author(s) -
Kawai Manabu,
Kondo Satoshi,
Yamaue Hiroki,
Wada Keita,
Sano Keiji,
Motoi Fuyuhiko,
Unno Michiaki,
Satoi Sohei,
Kwon AHon,
Hatori Takashi,
Yamamoto Masakazu,
Matsumoto Joe,
Murakami Yoshiaki,
Doi Ryuichiro,
Ito Masahiro,
Miyakawa Shuichi,
Shinchi Hiroyuki,
Natsugoe Shoji,
Nakagawara Hisatoshi,
Ohta Tetsuo,
Takada Tadahiro
Publication year - 2011
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-011-0373-x
Subject(s) - pancreatic fistula , medicine , pancreaticoduodenectomy , perioperative , receiver operating characteristic , odds ratio , gastroenterology , pancreas , logistic regression , fistula , surgery , general surgery
Background/purpose It is important to predict the development of clinically relevant pancreatic fistula (grade B/C) in the early period after pancreaticoduodenectomy (PD). This study has been carried out as a project study of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHPBS) to evaluate the predictive factors associated with clinically relevant pancreatic fistula (grade B/C). Method The data of 1,239 patients from 11 medical institutions who had undergone PD between July 2005 and June 2009 were retrospectively analyzed to review patient characteristics and perioperative and postoperative parameters. Results A drain amylase level >4,000 IU/L on postoperative day (POD) 1 was proposed as the cut‐off level to predict clinical relevant pancreatic fistula by the receiver operating characteristic (ROC) curve. The sensitivity, specificity, and accuracy of this cut‐off level were 62.2, 89.0, and 84.8%, respectively. A multivariate logistic regression analysis revealed that male [odds ratio (OR) 1.7, p = 0.039], intraoperative bleeding >1,000 ml (OR 2.5, p = 0.001), soft pancreas (OR 2.7, p = 0.001), and drain amylase level on POD 1 >4,000 IU/L (OR 8.6, p < 0.001) were the significant predictive factors for clinical pancreatic fistula. Conclusion The four predictive risk factors identified here can provide useful information useful for tailoring postoperative management of clinically relevant pancreatic fistula (grade B/C).