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The outcomes of methicillin‐resistant Staphylococcus aureus infection after living donor liver transplantation in a Japanese center
Author(s) -
Takatsuki Mitsuhisa,
Eguchi Susumu,
Yamanouchi Kosho,
Hidaka Masaaki,
Soyama Akihiko,
Miyazaki Kensuke,
Tajima Yoshitsugu,
Kanematsu Takashi
Publication year - 2010
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1007/s00534-010-0273-5
Subject(s) - medicine , linezolid , bacteremia , teicoplanin , liver transplantation , transplantation , pneumonia , mupirocin , methicillin resistant staphylococcus aureus , surgery , peritonitis , staphylococcus aureus , vancomycin , antibiotics , biology , bacteria , microbiology and biotechnology , genetics
Objective The objective of this study is to present results from our review of methicillin‐resistant Staphylococcus aureus (MRSA) infection in living‐donor liver transplant (LDLT) recipients. Methods Seventy patients with primary LDLT between August 1997 and May 2007 were retrospectively reviewed. Results Overall, 9 patients (12.9%) encountered various kinds of MRSA infection after transplantation [peritonitis (6), bacteremia (6), pneumonia (3), wound infection (3), cholangitis (1)]; 4 of these 9 patients died. Of these 4 expired patients, 3 were highly urgent cases with very poor pretransplant status under ventilator support. In one patient, linezolid was effective after teicoplanin failure for severe systemic MRSA infections (bacteremia, peritonitis, cholangitis, pneumonia, and enteritis). Of the 4 patients in whom MRSA was isolated only in a nasal swab before transplantation, none developed MRSA infection after transplantation with a 3‐day course of mupirocin prophylaxis. Conclusions MRSA infection was a contributing factor in death after transplantation in cases with poor pretransplant status. Linezolid was effective even for treating systemic MRSA infection after LDLT. A short course of mupirocin prophylaxis seemed to be effective and did not have any adverse effects.