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Intraductal oncocytic papillary neoplasm of the bile duct: the first case of peribiliary gland origin
Author(s) -
Nakanishi Yoshitsugu,
Zen Yoh,
Hirano Satoshi,
Tanaka Eiichi,
Takahashi Osamu,
Yonemori Atsuya,
Doumen Hiromitsu,
Kawakami Hiroshi,
Itoh Tomoo,
Nakanuma Yasuni,
Kondo Satoshi
Publication year - 2009
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-009-0070-1
Subject(s) - papillary tumor , pathology , bile duct , medicine , cystic duct , papillary adenocarcinoma , adenocarcinoma , intraductal papillary mucinous neoplasm , neoplasm , duct (anatomy) , common bile duct , cancer , pancreas
We report herein the first case of intraductal oncocytic papillary neoplasm of the bile duct arising from a peribiliary gland of the left hepatic duct. The patient was a 63‐year‐old Japanese man. Radiological and cholangioscopic examinations revealed intraductal tumor of the left hepatic duct. After pathological diagnosis of adenocarcinoma by cholangioscopic biopsy, a surgical hepatobiliary resection was performed. Pathological examination revealed papillary tumor in the left hepatic duct. Histologically, the tumor was identified as papillary neoplasm comprising oncocytic cells and delicate fibrovascular cores. Interestingly, this tumor originated from the cystic space in the bile duct wall. This cystic space was histologically identified as a cystically dilated peribiliary gland. Carcinoma in situ was observed in this cystic peribiliary gland at the bottom of the tumor, but not on any areas of biliary epithelium. This case suggests that intraductal papillary neoplasm can arise from both biliary epithelium and peribiliary glands.