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Quality control for clinical islet transplantation: organ procurement and preservation, the islet processing facility, isolation, and potency tests
Author(s) -
Yamamoto Toshiyuki,
Horiguchi Akihiko,
Ito Masahiro,
Nagata Hideo,
Ichii Hirohito,
Ricordi Camillo,
Miyakawa Shuichi
Publication year - 2009
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-009-0064-z
Subject(s) - islet , transplantation , immunosuppression , isolation (microbiology) , medicine , potency , organ transplantation , islet cell transplantation , intensive care medicine , diabetes mellitus , immunology , biology , bioinformatics , endocrinology , in vitro , biochemistry
Pancreatic islet transplantation has become one of the ideal treatments for patients with type 1 diabetes mellitus due to improvements in isolation techniques and immunosuppression regimens. In order to ensure the safety and rights of patients, isolated islets need to meet the criteria for regulation as both a biological product and a drug product. For the constant success of transplantation, therefore, all investigators involved in clinical islet transplantation must strive to ensure the safety, purity, and potency of islets in all the phases of clinical islet isolation and transplantation. In this review, we summarize the quality control for clinical islet isolation and transplantation, and the latest topics of pre‐transplant islet assessment.