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Effect of early antibiotic prophylaxis with ertapenem and meropenem in experimental acute pancreatitis in rats
Author(s) -
Catena Fausto,
Ansaloni L.,
Gazzotti F.,
Pezzilli R.,
Nanetti A.,
Santini D.,
Nardo B.,
Pinna A. D.
Publication year - 2009
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-009-0047-0
Subject(s) - ertapenem , meropenem , antibiotics , medicine , pancreatitis , carbapenem , antibiotic prophylaxis , gastroenterology , acute pancreatitis , microbiology and biotechnology , antibiotic resistance , biology
Background The clinical course in acute necrotizing pancreatitis is mainly influenced by bacterial infection of pancreatic and peripancreatic necrosis. The effect of two antibiotic treatments for early prophylaxis was studied in the taurocholate model of necrotizing pancreatitis in the rat. Methods Sixty male Sprague‐Dawley rats were divided into three pancreatitis groups (15 animals each) and a sham‐operated group (15 animals, control group). Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals were placed on one of two different antibiotic regimens (15 mg/kg ertapenem or 20 mg/kg meropenem, one shot) after the induction of pancreatitis or received no antibiotics (control). All animals were sacrificed after 24 h to study pancreatic and extrapancreatic infection. Results Early antibiotic prophylaxis with either erapenam or meropenem significantly decreased pancreatic infection from 12/15 (control group) to 4/15 (ertapenem antibiotic group) and 3/15 (meropenem antibiotic group) ( P < 0.05). Conclusions In our animal model of necrotizing pancreatitis, early antibiotic prophylaxis with ertapenem and meropenem reduced bacterial infection of the pancreas. The efficacy of early antibiotic prophylaxis with ertapenem in the clinical setting should be subject to further research.