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Contribution of 18 F‐fluorodeoxyglucose positron emission tomography to the diagnosis of early pancreatic carcinoma
Author(s) -
Seo Satoru,
Doi Ryuichiro,
Machimoto Takafumi,
Kami Kazuhiro,
Masui Toshihiko,
Hatano Etsuro,
Ogawa Kohei,
Higashi Tatsuya,
Uemoto Shinji
Publication year - 2008
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-007-1339-x
Subject(s) - medicine , standardized uptake value , pancreatic cancer , positron emission tomography , pancreas , nuclear medicine , fluorodeoxyglucose , radiology , cancer , carcinoma , pancreatic carcinoma , cutoff , pathology , physics , quantum mechanics
Background/Purpose Pancreatic carcinoma has a poor prognosis, and early detection is essential to allow potentially curative resection. Despite the wide array of diagnostic tools available, the detection of small pancreatic tumors remains difficult. The aim of this study was to investigate the contribution of 18 F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) to the diagnosis of early pancreatic cancer. Methods FDG‐PET was performed in 56 patients with pancreatic cancer who underwent curative surgery. The standardized uptake value (SUV) for FDG was calculated in each patient and the relationships between the SUV and various clinicopathological factors were analyzed. Results The tumors ranged from 0.8 to 6.5 cm in diameter. When the cutoff value for the SUV was set at 2.5, 51 of the 56 patients (91%) had a positive FDG‐PET study. The SUV did not show a significant difference in relation to tumor differentiation or pTS and pT factors. There was also no correlation between the SUV and the maximum tumor diameter ( r = 0.22; P = 0.1). Five tumors had an SUV below the cutoff value, and all of these lesions had intermediate or scirrhous stroma rather than medullary stroma. Conclusions These results indicate that FDG‐PET is useful for the detection of small early pancreatic cancers.