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T‐tube drainage stimulates the healing of choledochocholedochostomies. An experimental study in pigs
Author(s) -
Laursen Henrik Blegvad,
Kannerup AnneSofie,
Oxlund Hans,
Yasuda Yoshikazu,
FunchJensen Peter,
Rokkjaer Mogens,
Mortensen Frank Viborg
Publication year - 2008
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-007-1322-6
Subject(s) - medicine , anastomosis , surgery , laparotomy , cholangiography , stenosis , breaking strength , drainage , decompression , tube (container) , biology , mechanical engineering , ecology , materials science , engineering , composite material
Background/Purpose We investigated the effect of T‐tube drainage on the healing of choledocho‐choledochostomies in pigs. Methods Twenty pigs with a median weight of 56 kg were used for the experiments. The pigs were randomized to two groups of ten. In all pigs the gallbladder was removed and the common bile duct was transected. In both groups continuity was re‐established by standardized single‐line, interrupted, and inverted sutures. In one group a T‐tube for decompression was inserted. On postoperative day 6, a laparotomy was performed. Pigs were investigated for signs of cholascos, and an intraoperative cholangiography was performed. The excised anastomosis was examined for breaking strength and collagen content. Blood samples were drawn prior to the first and the final operations. Results In both groups standard liver parameters were unaffected by surgery, and cholangiography showed no signs of extrahepatic stenosis or intrahepatic dilatation. The T‐tubedrained choledocho‐choledochostomies showed a significantly higher breaking strength ( P = 0.035) compared to the group which had no drainage. Collagen content per volume was unaffected by T‐tube drainage. Conclusions T‐tube drainage had a significant stimulatory effect on the breaking strength of choledocho‐choledochostomies in pigs on postoperative day 6, but was without effect on collagen content.