Premium
Intrahepatic dissemination of hepatocellular carcinoma after local ablation therapy
Author(s) -
Masuda Toshiro,
Beppu Toru,
Ishiko Takatoshi,
Horino Kei,
Baba Yoshifumi,
Mizumoto Takao,
Hayashi Hiromitsu,
Okabe Hirohisa,
Horlad Hasita,
Doi Koichi,
Okabe Kazutoshi,
Takamori Hiroshi,
Hirota Masahiko,
Iyama KenIchi,
Baba Hideo
Publication year - 2008
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-007-1288-4
Subject(s) - medicine , hepatocellular carcinoma , ablation , intrahepatic cholangiocarcinoma , portal vein , radiology , vein , biopsy
Background/Purpose We aimed to clarify the histological features of and risk factors for intrahepatic dissemination after local ablation therapy (LAT) for hepatocellular carcinoma (HCC). Methods Between April 1992 and December 2005, 192 HCC patients underwent hepatic resection at our department, among whom were 17 patients who had local recurrences after LAT. Eight of these 17 patients had intrahepatic dissemination. The clinical and histological characteristics of these 8 surgically treated patients with intrahepatic dissemination were investigated. Results Histologically, numerous intrahepatic metastases were observed, mainly in the same section as the treated tumor, together with main or sectional portal vein tumor thrombi. Before the ablation therapy, the average tumor diameter was 2.1 cm, and 62.5% of the tumors were adjacent to the main or sectional portal vein. In terms of therapeutic factors, 25% of the patients had a prior needle biopsy and 62.5% had insufficient safety margins. Conclusions LAT for HCCs (even those less than 3 cm in diameter) adjacent less than 5 mm to the main or sectional portal vein possibly promotes intrahepatic dissemination.