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Surgical outcome of solid pseudopapillary tumor of the pancreas
Author(s) -
Nakagohri Toshio,
Kinoshita Taira,
Konishi Masaru,
Takahashi Shinichirou,
Gotohda Naoto
Publication year - 2008
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-007-1264-z
Subject(s) - medicine , enucleation , pancreas , duodenum , pancreaticoduodenectomy , pancreatectomy , neuroendocrine tumors , standardized uptake value , radiology , calcification , positron emission tomography , surgery
Background/Purpose The best surgical treatment for solid pseudopapillary tumor of the pancreas is a matter of debate. Methods Fourteen patients with solid pseudopapillary tumor of the pancreas who underwent surgical resection, including enucleation, between June 1996 and January 2007 were retrospectively analyzed to evaluate the effect of the treatment. Results The mean age of the patients was 39 years (range, 15 to 59 years). The mean size of the tumor was 4.4 cm (range, 2.0 to 12 cm). Ten tumors (71%) had a well‐defined capsule, and 6 tumors (43%) extended beyond the pancreas. Eight of the 14 tumors (57%) had a cystic component, and calcification was observed in 6 tumors (43%). The frequency of microscopic venous invasion, lymphatic invasion, and nerve invasion was 29% (4 of 14), 0%, and 21% (3 of 14), respectively. No lymph node involvement or liver metastasis was observed. Six patients underwent positron emission tomography with 2‐deoxy‐2‐[ 18 F] fluoro‐D‐glucose (FDG), and stronger FDG accumulation compared with the surrounding pancreatic parenchyma was observed in 5 of the 6 patients. The median standardized uptake value (SUV) was 6.3 (range, 0.9 to 42.8). Distal pancreatectomy ( n = 5), subtotal stomach‐preserving pancreatoduodenectomy ( n = 3), local resection ( n = 3), enucleation ( n = 2), and duodenum‐preserving pancreatic head resection ( n = 1) were performed. Overall morbidity and mortality rates were 43% and 0%, respectively. All patients were still alive without recurrent disease after a median follow‐up of 46 months. Conclusions Patients with solid pseudopapillary tumor of the pancreas had a favorable outcome after surgical treatment, including enucleation.