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Do we need histology for a normal‐looking gallbladder?
Author(s) -
Bazoua George,
Hamza Numan,
Lazim Taha
Publication year - 2007
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-007-1225-6
Subject(s) - gallbladder , medicine , gallbladder cancer , cholecystectomy , gallstones , malignancy , dysplasia , cancer , radiology , gallbladder disease , carcinoma , abdominal ultrasound , histology , gastroenterology , pathology , general surgery
Background/Purpose Gallbladder cancer (GBC) is a rare malignancy with poor overall prognosis. Simple cholecystectomy is curative if the cancer is limited to mucosa. We aimed here to investigate the need for routine histological examination of gallbladder. Methods We carried out a retrospective review of 2890 final pathology reports of processed gallbladder specimens following cholecystectomy due to gallstones disease. The review covered the 10‐year period from 1994 to 2004. The notes of all cases of gallbladder cancer were scrutinized, with particular emphasis on presentation, preoperative diagnostic tools using abdominal ultrasound and computed tomography scan, operative findings, and the histology results. Results Gallbladder cancer (GBC) was detected in five specimens (0.17%), dysplasia in six (0.2%), and secondaries to gallbladder in three (0.1%). Histological findings confirmed gallstone disease in 97% and rare benign pathology in 3%. The median age of patients with GBC was 61 years (range, 59–84 years). In all five patients, cancer was isolated from thickened fibrotic wall on macroscopic appearance and spread through all layers of the gallbladder wall. The percentage of thickened‐wall gallbladder in this study was 38.02% and the cancer incidence in the thickened wall was 0.45%. Conclusions A selective policy rather than routine histological examination of nonfibrotic or thickened‐wall gallbladder has to be considered. This will reduce the burden on pathology departments, with significant cost savings.