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Molecular genetics of intraductal papillary—mucinous neoplasms of the pancreas
Author(s) -
Furukawa Toru
Publication year - 2007
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-006-1167-4
Subject(s) - kras , pancreas , cdkn2a , stk11 , pathology , cancer research , gnas complex locus , pten , biology , medicine , pi3k/akt/mtor pathway , cancer , gene , colorectal cancer , signal transduction , genetics
Intraductal papillary—mucinous neoplasms of the pancreas show characteristic clinicopathological and molecular pathobiological features which are distinct from those of conventional ductal adenocarcinomas. Alterations of KRAS, AKT/PKB , CDKN2A , TP53 , SMAD4 , STK11/LKB1 , and DUSP6 , and other molecular alterations, including global expression studies as well as their clinical implications, are discussed.