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Risk factors contributing to hepatic artery thrombosis following living‐donor liver transplantation
Author(s) -
Ikegami Toshihiko,
Hashikura Yasuhiko,
Nakazawa Yuichi,
Urata Koichi,
Mita Atsuyoshi,
Ohno Yasunari,
Terada Masaru,
Miyagawa Shinichi,
Kushima Hideo,
Kondoh Shoji
Publication year - 2006
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-005-1015-y
Subject(s) - medicine , thrombosis , liver transplantation , transplantation , artery , population , liver disease , surgery , gastroenterology , cardiology , environmental health
Background/Purpose This study was carried out to investigate the risk factors contributing to hepatic artery thrombosis in living‐donor liver transplantation. Methods Two hundred and twenty‐two recipients (113 adults and 109 children) of living‐donor liver transplantation were the subjects of this study. The diagnosis of hepatic artery thrombosis was made by color‐Doppler ultrasonography and/or hepatic angiography. Parameters for this study were: (1) donor sex, age, and body weight; (2) recipient sex, age, body weight, liver disease, preoperative prothrombin time, and type of arterial reconstruction; and (3) previous liver transplantation. Results Hepatic artery thrombosis occurred in 12 patients (5.4%) at 3 to 15 days posttransplant. Recipient female sex and metabolic disorder as the original disease were found to be significantly associated with hepatic artery thrombosis. The 5‐year patient survival rate in recipients with hepatic artery thrombosis (58.3%) was significantly lower than that in recipients without this complication (84.4%). Conclusions Female sex and metabolic disease may be factors contributing to hepatic artery thrombosis after living‐donor liver transplantation. More intensive anticoagulation therapy for this patient population might decrease the incidence of hepatic artery thrombosis and, thus, posttransplant recipient mortality.