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Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms
Author(s) -
Kuroki Tamotsu,
Tajima Yoshitsugu,
Kanematsu Takashi
Publication year - 2005
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-005-1004-1
Subject(s) - hepatolithiasis , intrahepatic cholangiocarcinoma , carcinogenesis , cancer , cancer research , medicine , gene , biology , oncology , resection , genetics , hepatectomy , surgery
Abstract Hepatolithiasis is more frequently seen in East Asian countries than in Western countries, and it is well known to represent a high‐risk state for intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma is an aggressive tumor that shows a dismal outcome even after resection. Cancer results from multistep carcinogenesis; however, the precise molecular mechanisms involved in the genetic alterations in cancer remain unknown. The accumulation of alterations in cancer‐related genes leads to disruptions in cell‐cycle regulation and also to continuous cell proliferation. The present review provides an overview of cancer‐related genes in intrahepatic cholangiocarcinogenesis arising in hepatolithiasis. Further study of molecular mechanisms in hepatolithiasis‐related intrahepatic cholangiocarcinoma, and the delineation of the influence of the genes involved should lead to our understanding of cholangiocarcinogenesis.