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Extrapulmonary small‐cell carcinoma of the liver
Author(s) -
Kim Young Hoon,
Kwon Ryuk,
Jung Ghap Joong,
Roh Myung Hwan,
Han Sang Young,
Kwon Hyuk Chan,
Jeong Jin Sook,
Shin Tae Beom,
Oh Jong Young,
Lee Ki Nam
Publication year - 2004
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-004-0904-9
Subject(s) - carcinoma , medicine , pathology
Abstract A 53‐year‐old man was admitted to our hospital for the evaluation of a mass (13 × 10 cm) in the left lobe of the liver seen by imaging studies. On subsequent biopsy of the mass, the lesion was histologically diagnosed as malignant small round‐cell tumor, consistent with metastatic small‐cell carcinoma. Segment IV segmentectomy was performed. On pathological examination, the mass showed a yellowish‐gray granular appearance with multifocal hemorrhage and necrosis. The phenotypes shown by immunohistochemistry revealed characteristic patterns of small‐cell carcinoma (neuron‐specific enolase [NSE]+, synaptophysin+, c‐Kit+, cluster designation [CD]56+, epithelial membrane antigen [EMA]+, cytokeratin [CK]7−). High resolution‐computed tomography (HRCT) revealed inactive pulmonary tuberculosis with small calcified tuberculoma in the right upper lobe. Sputum cytology was negative for malignancy. The postoperative course was uneventful, and platinum‐based chemotherapy (cisplatin, etoposide) was initiated.