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Ischemia‐reperfusion injury of the human liver during hepatic resection
Author(s) -
Kim YangIl
Publication year - 2003
Publication title -
journal of hepato‐biliary‐pancreatic surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 0944-1166
DOI - 10.1007/s00534-002-0730-x
Subject(s) - hepatoduodenal ligament , medicine , ischemia , reperfusion injury , hepatectomy , vascular occlusion , occlusion , limiting , liver injury , liver transplantation , surgery , resection , transplantation , mechanical engineering , engineering
Haemorrhage during resection of the liver remains a significant threat to clinical outcome. Portal triad occlusion, with complete clamping of the hepatic inflow at the hepatoduodenal ligament, is a well‐documented, safe, and useful means of alleviating this problem. Although this technique is effective in limiting blood loss, there is still controversy concerning the potential drawbacks of ischemia and subsequent reperfusion injury of the liver. This article highlights recent advances in our understanding of the clinical factors influencing ischemia‐reperfusion injury of the liver, particularly in human patients. These factors include the cell components involved, the mechanisms that enable the human liver to tolerate long‐term inflow occlusion, factors affecting clinical outcomes, and surgical and pharmacological techniques used to alleviate ischemia‐reperfusion injury, including hypothermic hepatectomy.