Open AccessTumor necrosis factor-alpha is associated with mineral bone disorder and growth impairment in children with chronic kidney disease
Author(s) -
Kelly Meza,
Sharmi Biswas,
YuanShan Zhu,
Anuradha Gajjar,
Eduardo Perelstein,
Juhi Kumar,
Oleh Akchurin
Publication year - 2021
Publication title -
pediatric nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 107
eISSN - 1432-198X
pISSN - 0931-041X
DOI - 10.1007/s00467-020-04846-3
Subject(s) - medicine , kidney disease , renal function , endocrinology , fibroblast growth factor 23 , nephrology , chronic kidney disease mineral and bone disorder , parathyroid hormone , alkaline phosphatase , vitamin d and neurology , renal osteodystrophy , calcium , biology , biochemistry , enzyme
Mineral and bone disorder (MBD) and growth impairment are common complications of pediatric chronic kidney disease (CKD). Chronic inflammation detrimentally affects bone health and statural growth in non-CKD settings, but the impact of inflammation on CKD-MBD and growth in pediatric CKD remains poorly understood. This study assessed associations between inflammatory cytokines with biomarkers of CKD-MBD and statural growth in pediatric CKD.