Open AccessBicarbonate, blood pressure, and executive function in pediatric CKD—is there a link?
Author(s) -
Lyndsay A. Harshman,
Amy J. Kogon,
Matthew B. Matheson,
Rebecca J. Johnson,
Shlomo Shinnar,
Arlene C. Gerson,
Bradley A. Warady,
Susan L. Furth,
Stephen R. Hooper,
Marc B. Lande
Publication year - 2020
Publication title -
pediatric nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 107
eISSN - 1432-198X
pISSN - 0931-041X
DOI - 10.1007/s00467-020-04507-5
Subject(s) - medicine , kidney disease , bicarbonate , renal function , blood pressure , nephrology , blood urea nitrogen , cardiology , endocrinology
In adult chronic kidney disease (CKD), metabolic acidosis is associated with diminished cognition, notably executive function (EF). Data from the Chronic Kidney Disease in Children (CKiD) study demonstrate a risk for impairment of EF, a finding associated with heightened blood pressure variability (BPV). We sought to determine whether low serum bicarbonate is also associated with performance on tests of EF in pediatric CKD and to investigate potential interaction with BPV.