Open AccessDoes MEST-C score predict outcomes in pediatric Henoch-Schönlein purpura nephritis?
Author(s) -
Adam Jimenez,
Ashton Chen,
Jen-Jar Lin,
Andrew M. South
Publication year - 2019
Publication title -
pediatric nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.831
H-Index - 107
eISSN - 1432-198X
pISSN - 0931-041X
DOI - 10.1007/s00467-019-04327-2
Subject(s) - medicine , proteinuria , renal function , kidney disease , nephrology , receiver operating characteristic , gastroenterology , nephropathy , logistic regression , cohort , creatinine , nephritis , renal biopsy , area under the curve , kidney , endocrinology , diabetes mellitus
Children with Henoch-Schönlein purpura nephritis (HSPN) have an increased risk of chronic kidney disease (CKD). Renal biopsy diagnostic of HSPN is graded using the International Study of Kidney Disease in Children criteria, which do not predict outcomes. The 2016 Oxford Classification's MEST-C scoring system predicts outcomes in adults with histologically identical IgA nephropathy, but evidence of its utility in pediatric HSPN is lacking. Our hypothesis was that MEST-C scores predict outcomes in children with HSPN.