Open AccessMetabolic effects of duodenojejunal bypass surgery in a rat model of type 1 diabetes
Author(s) -
Pieter Gillard,
Rickesha Wilson,
Gautam Sharma,
Suriya Punchai,
Ricard Corcelles,
Dvir Froylich,
Anny Mulya,
Philip R. Schauer,
Stacy A. Brethauer,
John P. Kirwan,
Naseer Sangwan,
J. Mark Brown,
Ali Aminian
Publication year - 2020
Publication title -
surgical endoscopy/surgical endoscopy and other interventional techniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.457
H-Index - 152
eISSN - 1432-2218
pISSN - 0930-2794
DOI - 10.1007/s00464-020-07741-y
Subject(s) - medicine , glucose homeostasis , insulin , diabetes mellitus , pancreas , type 1 diabetes , endocrinology , streptozotocin , gastroenterology , insulin resistance
Metabolic surgery has beneficial metabolic effects, including remission of type 2 diabetes. We hypothesized that duodenojejunal bypass (DJB) surgery can protect against development of type 1 diabetes (T1D) by enhancing regulation of cellular and molecular pathways that control glucose homeostasis.