Open AccessMolecular imaging and theranostic approaches in pheochromocytoma and paraganglioma
Author(s) -
David Taïeb,
Karel Pacák
Publication year - 2018
Publication title -
cell and tissue research/cell and tissue research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.64
H-Index - 137
eISSN - 1432-0878
pISSN - 0302-766X
DOI - 10.1007/s00441-018-2791-4
Subject(s) - paraganglioma , pheochromocytoma , neural crest , neuroendocrine tumors , molecular imaging , cancer research , computational biology , medicine , pathology , neuroscience , biology , bioinformatics , microbiology and biotechnology , genetics , in vivo , embryo
Pheochromocytomas and their extra-adrenal counterpart paragangliomas (PGLs; together called PPGLs), belong to the family of neural crest-derived tumors. Given the overexpression of a wide variety of specific targets in PPGLs, it seems that these tumors are optimally suited to be imaged by specific radiopharmaceuticals. Thus, theranostics approaches with somatostatin agonists and antagonists are rapidly evolving in the setting of these tumors and may be considered as the next step in the therapeutic arsenal of metastatic PPGLs.