Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation | Zendy

Marian A. J. Weterman | Zendy; M. Wilbrink | Zendy; Trijnie Dijkhuizen | Zendy; Anke van den Berg | Zendy; Ad Geurts van Kessel | Zendy

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Fine mapping of the 1q21 breakpoint of the papillary renal cell carcinoma-associated (X;1) translocation

Author(s) -

Marian A. J. Weterman,

M. Wilbrink,

Trijnie Dijkhuizen,

Anke van den Berg,

Ad Geurts van Kessel

Publication year - 1996

Publication title -

human genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.351

H-Index - 137

eISSN - 1432-1203

pISSN - 0340-6717

DOI - 10.1007/s004390050153

Subject(s) - breakpoint , biology , chromosomal translocation , synteny , fluorescence in situ hybridization , microbiology and biotechnology , genetics , somatic cell , chromosome , gene mapping , southern blot , gene

A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization (FISH) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma (RCC)-associated (X;1)-(p11;q21) translocation. This breakpoint maps between several members of the S100 family which are clustered in the 1q21 region and a conserved region between man and mouse containing the markers SPTA1-CRP-APCS-FcER1A-ATP1A2-APOA2. The location of the breakpoint coincides with the transition of a region of synteny of human chromosome 1 with mouse chromosomes 3 and 1.

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