Open AccessThe PI3K pathway impacts stem gene expression in a set of glioblastoma cell lines
Author(s) -
E. Martínez,
Neftalí Vázquez,
Alma Lopez,
Victor Fanniel,
Lilia Sánchez,
Rebecca Marks,
Leetoria Hinojosa,
Victoria Cuello,
Marisa Cuevas,
Angelica Rodriguez,
Cerin Tomson,
Andrea Salinas,
Mark S. Abad,
Martin Holguin,
Noel Garza,
Abraham J. Arenas,
K. E. Abraham,
Luís A. Maldonado,
Vivian Rojas,
Alex Basdeo,
Erin Schuenzel,
Michael W. Persans,
Wendy InnisWhitehouse,
Megan Keniry
Publication year - 2020
Publication title -
journal of cancer research and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 94
eISSN - 1432-1335
pISSN - 0171-5216
DOI - 10.1007/s00432-020-03133-w
Subject(s) - pi3k/akt/mtor pathway , biology , stem cell , foxo3 , cancer stem cell , cancer research , embryonic stem cell , sox2 , regulation of gene expression , gene expression , signal transduction , microbiology and biotechnology , protein kinase b , gene , genetics
The PI3K pathway controls diverse cellular processes including growth, survival, metabolism, and apoptosis. Nuclear FOXO factors were observed in cancers that harbor constitutively active PI3K pathway output and stem signatures. FOXO1 and FOXO3 were previously published to induce stem genes such as OCT4 in embryonic stem cells. Here, we investigated FOXO-driven stem gene expression in U87MG glioblastoma cells.